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A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists.

Abstract：

:A new efficient synthetic method to obtain prokineticin receptor antagonists based on the triazinedione scaffold is described. In this procedure the overall yield improves from 13% to about 54%, essentially for two factors: 1) N-(chlorocarbonyl) isocyanate is no more used, it represents the yield limiting step with an average yield not exceeding 30%. 2) The Mitsunobu reaction is not involved in the new synthetic scheme avoiding the use of time and solvent consuming column chromatography. All synthesized triazinediones were preliminary pharmacologically screened in vivo for their ability to reduce the Bv8-induced thermal hyperalgesia. In this assay all compounds displayed EC50 values in the picomolar-subpicomolar range, some triazinediones containing a 4-halogen substituted benzyl group in position 5 showed the best activity. The analogues containing a 4-fluorine atom (PC-7) and a 4-bromobenzyl group (PC-25) resulted 10 times more potent than the reference PC-1 that bears a 4-ethylbenzyl group. While the 4-trifluoromethylbenzyl substituted analog (PC-27) was 100 times more potent as compared to PC1.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Congiu C,Onnis V,Deplano A,Salvadori S,Marconi V,Maftei D,Negri L,Lattanzi R,Balboni G

doi

10.1016/j.ejmech.2014.05.030

subject

Has Abstract

pub_date

2014-06-23 00:00:00

pages

334-40

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00444-9

journal_volume

81

pub_type

杂志文章

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