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Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach.

Abstract：

:Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Chande MS,Verma RS,Barve PA,Khanwelkar RR,Vaidya RB,Ajaikumar KB

doi

10.1016/j.ejmech.2005.06.004

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

1143-8

issue

11

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(05)00174-1

journal_volume

40

pub_type

杂志文章

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