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Influence of enantiomers of 1-naphthylalanine in position 2 of VAVP and dVAVP on their pharmacological properties.

Abstract：

:In this study, we described the synthesis and some pharmacological properties of four new analogues of arginine vasopressin (AVP). Two peptides are substituted in position 2 with L-1-naphthylalanine (L-1-Nal) or its D-enantiomer and in position 4 with valine. In the further two compounds, we combined the above modifications with placement into position 1 of 3-mercaptopropionic acid residue (Mpa). All new peptides were tested for vasopressor and antidiuretic activities. We also estimated the uterotonic activities of these compounds in vitro. Urine samples prior and after peptide administration were analyzed for electrolytes excretion. All analogues are potent oxytocin antagonists. One of them, namely [L-1-Nal2,Val4]AVP, which appears practically not to interact with V1a and V2 receptors, is exceptionally selective. Our results open new possibilities for the design of very potent and selective oxytocin antagonists in vitro.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Derdowska I,Prahl A,Kowalczyk W,Janecki M,Melhem S,Trzeciak HI,Lammek B

doi

10.1016/j.ejmech.2004.09.011

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

63-8

issue

1

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(04)00195-3

journal_volume

40

pub_type

杂志文章

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