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NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).

Abstract：

:This paper describes molecular docking studies of a series of classical NSAIDs with PPARgamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARgamma activation by non-selective COX inhibitors.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Romeiro NC,Sant'Anna CM,Lima LM,Fraga CA,Barreiro EJ

doi

10.1016/j.ejmech.2007.11.031

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

1918-25

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00463-1

journal_volume

43

pub_type

杂志文章

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