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Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.

Abstract：

:Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ito C,Itoigawa M,Kanematsu T,Imamura Y,Tokuda H,Nishino H,Furukawa H

doi

10.1016/j.ejmech.2006.12.024

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

902-9

issue

7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00023-2

journal_volume

42

pub_type

杂志文章

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