Abstract:
:Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Siddiqui AA,Mishra R,Shaharyar Mdoi
10.1016/j.ejmech.2010.02.003subject
Has Abstractpub_date
2010-06-01 00:00:00pages
2283-90issue
6eissn
0223-5234issn
1768-3254pii
S0223-5234(10)00120-0journal_volume
45pub_type
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