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2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

Abstract：

:Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Raffa D,Maggio B,Raimondi MV,Cusimano MG,Amico G,Carollo A,Conaldi PG,Bai R,Hamel E,Daidone G

doi

10.1016/j.ejmech.2013.04.068

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

427-35

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(13)00301-2

journal_volume

65

pub_type

杂志文章

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