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Angiotensin II--AT1 receptor antagonists: design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives.

Abstract：

:A series of 5-(alkyl and aryl)carboxamido benzimidazole derivatives had been designed, synthesized and evaluated for in vitro angiotensin II--AT1 receptor antagonism and in vivo antihypertensive activities. The pharmacological activities were inversely related to the size of alkyl and aryl substituents. It can be suggested that compounds with lower alkyl groups at 5-position of benzimidazole nucleus demonstrated potent antihypertensive activity.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Shah DI,Sharma M,Bansal Y,Bansal G,Singh M

doi

10.1016/j.ejmech.2007.11.008

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

1808-12

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00441-2

journal_volume

43

pub_type

杂志文章

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