Abstract：
:Six transition metal compounds of Schiff base ligands were evaluated for the inhibitory activity on jack bean urease, of which compounds 2-6 were determined by single crystal X-ray analysis. It was found that copper(II) complexes 1 and 4 showed strong inhibitory activity against jack bean urease (IC(50) = 0.52 and 0.46 microM), compared with acetohydroxamic acid (IC(50) = 42.12 microM) as a positive reference. Cobalt(II), nickel(II) and zinc(II) compounds also exhibited potent inhibitory activity (IC(50) = 3.88-25.20 microM). A docking analysis using the AUTODOCK 4.0 program could explain the inhibitory activities of 1 and 4 against urease.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Chen W,Li Y,Cui Y,Zhang X,Zhu HL,Zeng Qdoi
10.1016/j.ejmech.2010.07.007subject
Has Abstractpub_date
2010-10-01 00:00:00pages
4473-8issue
10eissn
0223-5234issn
1768-3254pii
S0223-5234(10)00487-3journal_volume
45pub_type
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