当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.

Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.

Abstract：

:Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Basabe P,de Román M,Marcos IS,Diez D,Blanco A,Bodero O,Mollinedo F,Sierra BG,Urones JG

doi

10.1016/j.ejmech.2010.06.025

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

4258-69

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00469-1

journal_volume

45

pub_type

杂志文章

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