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New and efficient approach for synthesis of novel bioactive [1,3,4]thiadiazoles incorporated with 1,3-thiazole moiety.

Abstract：

:A series of novel 1,3,4-thiadiazoles incorporated with thiazole moiety was synthesized by reaction of 5-acetyl-2-benzoylimino-3-phenyl-1,3,4-thiadiazole thiosemicarbazone 2 with each of N-phenyl 2-oxo-propanehydrazonoyl chloride 3 and ethyl (N-aryl-hydrazono) chloroacetate 5 in dioxane in basic medium. Also, another series of 1,3,4-thiadiazole incorporated with thiazole moiety was prepared by reaction of 5-acetyl-2-benzoylimino-3-phenyl-1,3,4-thiadiazole thiocarbohydrazone with each of hydrazonoyl chlorides 3, 5 and 18 under the same reaction conditions. The mechanisms of the studied reactions were discussed and the assigned structure for each of the new products was identified via elemental and spectral data and by alternative method whenever possible. Moreover, the antimicrobial activity for some selected products was screened, and the results obtained exploring the high potency of some of the tested compounds compared with the employed standard bactericides and fungicide.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Farghaly TA,Abdallah MA,Masaret GS,Muhammad ZA

doi

10.1016/j.ejmech.2015.05.009

subject

Has Abstract

pub_date

2015-06-05 00:00:00

pages

320-33

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(15)30036-2

journal_volume

97

pub_type

杂志文章

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