当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.

Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.

Abstract：

:Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Rizk OH,Shaaban OG,El-Ashmawy IM

doi

10.1016/j.ejmech.2012.07.007

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

85-93

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(12)00419-9

journal_volume

55

pub_type

杂志文章

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