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Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.

Abstract：

:The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Almerico AM,Mingoia F,Diana P,Barraja P,Montalbano A,Lauria A,Loddo R,Sanna L,Delpiano D,Setzu MG,Musiu C

doi

10.1016/s0223-5234(01)01289-2

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

3-10

issue

1

eissn

0223-5234

issn

1768-3254

pii

S0223523401012892

journal_volume

37

pub_type

杂志文章

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