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Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen.

Abstract：

:A series of novel ketoprofen derivatives 4a-j bearing both amide and carbamate functionalities were prepared using benzotriazole. Selective reduction of ketoprofen produced hydroxy derivative 2, which reacts with one or 2 mol of 1-benzotriazole carboxylic acid chloride (1) gave benzotriazole derivatives 3a and 3b respectively. Antioxidative screenings revealed that the prepared compounds 3b and 4a-j possess excellent lipid peroxidation inhibition at 0.1 mM concentration. Two of the compounds 3b and 4 g also showed high soybean lipoxygenase inhibition activity, where as the amidocarbamate derivatives of ketoprofen showed only weak reducing activity against 1,1-diphenyl-2-picrylhydrazyl radicals. No selective antiviral effects were noted for the tested compounds against a broad variety of DNA and RNA viruses.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Sahoo PK,Behera P

doi

10.1016/j.ejmech.2010.04.008

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

3162-8

issue

7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00290-4

journal_volume

45

pub_type

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