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New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization.

Abstract：

:The design and synthesis of a series of new fluorescent coumarin-containing melatonin analogues is presented. The combination of high-binding affinities for human melatonergic receptors (h-MT₁R and h-MT₂R) and fluorescent properties, derived from the inclusion of melatonin pharmacophoric elements in the coumarin scaffold, yielded suitable candidates for the development of MT₁R and MT₂R fluorescent probes for imaging in biological media.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

de la Fuente Revenga M,Herrera-Arozamena C,Fernández-Sáez N,Barco G,García-Orue I,Sugden D,Rivara S,Rodríguez-Franco MI

doi

10.1016/j.ejmech.2015.09.003

subject

Has Abstract

pub_date

2015-10-20 00:00:00

pages

370-3

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(15)30247-6

journal_volume

103

pub_type

杂志文章

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