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Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.

Abstract：

:An efficient synthesis of dialkylsubstituted maleic anhydrides 1a-j is described. The inhibitory potential of these original anhydride derivatives was tested toward the three human isoforms A, B and C of dual specific phosphatases Cdc25. A micromolar range inhibition of Cdc25s was observed with the maleic anhydrides bearing simple alkyl side chains longer than C(9), to reach the optimal activity with a C(17) chain length.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Brault L,Denancé M,Banaszak E,El Maadidi S,Battaglia E,Bagrel D,Samadi M

doi

10.1016/j.ejmech.2006.09.014

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

243-7

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(06)00349-7

journal_volume

42

pub_type

杂志文章

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