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Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

Abstract：

:The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Qiao Y,Maiti K,Sultana Z,Fu L,Smith R

doi

10.1016/j.ejmech.2019.111948

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

111948

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(19)31100-6

journal_volume

187

pub_type

杂志文章,评审

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