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Benzoxazoles and oxazolopyridines in medicinal chemistry studies.

Abstract：

:The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. By analysis of published X-ray structures, this review aims at highlighting key interactions which the benzoxazole may engage in with its host protein. Furthermore, bioavailability, metabolism and the use of benzoxazole as a bioisostere are discussed. The review is extended to cover structure-activity relationship studies of 2-substituted benzoxazoles, 2-substituted oxazolopyridines, and in perspective, application of the recently published novel heterocycle oxazolopyrazine in medicinal chemistry studies.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Demmer CS,Bunch L

doi

10.1016/j.ejmech.2014.11.064

subject

Has Abstract

pub_date

2015-06-05 00:00:00

pages

778-85

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)01106-4

journal_volume

97

pub_type

杂志文章,评审

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