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A macrolactone from benzo[a]phenazine with potent activity against Mycobacterium tuberculosis.

Abstract：

:We report here an alternative to the MCPBA or ozonolysis-based oxidation methods of quinoxaline-featuring compounds prepared from beta-lapachones. The use of peracetic acid allowed a simple preparation of the corresponding macrolactones by cleavage of the ring system. These lactones were evaluated for their antimycobacterial potential and compound 4 turned out to have an MIC of 0.62 microg per mL on Mycocabteriumtuberculosis H37Rv. These results justify further research into its value as a potential lead for an original treatment of tuberculosis.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Silva RS,Pinto Mdo C,Goulart MO,de Souza Filho JD,Neves I Jr,Lourenço MC,Pinto AV

doi

10.1016/j.ejmech.2008.06.014

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

2334-7

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00312-7

journal_volume

44

pub_type

杂志文章

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