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Recent insights into synthetic β-carbolines with anti-cancer activities.

Abstract：

:Cancer, an uncontrolled and rapid proliferation of abnormal cells, has become one of the leading cause of death worldwide. The development of resistance among the numerous drugs in clinical use has provided strong impetus for the identification and development of novel cancer therapeutics. β-carbolines constitute an important class of pharmacologically active scaffolds known to exert their anticancer activities via diverse mechanisms. The purpose of present review article is to update the readers on the current developments in β-carbolines with an emphasis on synthetic strategies, structure-activity relationships, mechanism of action and in vivo studies wherever possible.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Kumar S,Singh A,Kumar K,Kumar V

doi

10.1016/j.ejmech.2017.05.059

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

48-73

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(17)30430-0

journal_volume

142

pub_type

杂志文章,评审

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