Abstract:
:By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 μM against TK+ and TK- VZV and without measurable cell-growth inhibition.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Kaoukabi H,Kabri Y,Curti C,Taourirte M,Rodriguez-Ubis JC,Snoeck R,Andrei G,Vanelle P,Lazrek HBdoi
10.1016/j.ejmech.2018.06.028subject
Has Abstractpub_date
2018-07-15 00:00:00pages
772-781eissn
0223-5234issn
1768-3254pii
S0223-5234(18)30519-1journal_volume
155pub_type
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