Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation.

Abstract:

:By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 μM against TK+ and TK- VZV and without measurable cell-growth inhibition.

journal_name

Eur J Med Chem

authors

Kaoukabi H,Kabri Y,Curti C,Taourirte M,Rodriguez-Ubis JC,Snoeck R,Andrei G,Vanelle P,Lazrek HB

doi

10.1016/j.ejmech.2018.06.028

subject

Has Abstract

pub_date

2018-07-15 00:00:00

pages

772-781

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(18)30519-1

journal_volume

155

pub_type

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