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Current research on hyaluronic acid-drug bioconjugates.

Abstract：

:Hyaluronic acid (HA) is a mucopolysaccharide acid composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. Based on numerous characteristics such as viscoelastic properties, water-binding ability, biocompatibility and non-immunogenicity, HA has been approved by FDA for biological and medical applications. In addition, multifarious receptors of HA like CD44, RHAMM and TSG6 are over-expressed on the surface of malignant cells, which play important roles in targeting ability. Bioconjugates linking drugs to HA could improve solubility, prolong half-life, provide active targeting capability and then increase the bioavailability of these coupled drugs by pro-drug strategy. Therefore, a large number of HA-drug bioconjugates have been studied. The purpose of this review was to summarize these HA-drug bioconjugates and further discuss synthetic methods and the relevant application in pharmaceuticals.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Zhang H,Huang S,Yang X,Zhai G

doi

10.1016/j.ejmech.2014.08.067

subject

Has Abstract

pub_date

2014-10-30 00:00:00

pages

310-7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00802-2

journal_volume

86

pub_type

杂志文章,评审

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