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Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.

Abstract：

:Di-n-butyltin(IV) carboxylate and tri-n-butyltin(IV) carboxylate derivatives have demonstrated strong cytotoxic effects in different types of tumor cells. Complexes with carboxylate ligands that contain maleimide and naphthalimide derived partial structures were synthesized, characterized and investigated for inhibition of the tumor-relevant enzyme thioredoxin reductase and antiproliferative effects in cancer cells. The complexes were moderate inhibitors of thioredoxin reductase with activities in the micromolar range and triggered strong cytotoxic effects in MCF-7 breast cancer and HT-29 colon carcinoma cells. Interestingly, selected complexes were highly active in vincristine and daunorubicin resistant Nalm-6 cells.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Navakoski de Oliveira K,Andermark V,Onambele LA,Dahl G,Prokop A,Ott I

doi

10.1016/j.ejmech.2014.09.075

subject

Has Abstract

pub_date

2014-11-24 00:00:00

pages

794-800

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00894-0

journal_volume

87

pub_type

杂志文章

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