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β-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: an update.

Abstract：

:The design of novel antitumor agents allowing the destruction of malignant cells while sparing healthy tissues is one of the major challenges in medicinal chemistry. In this context, the use of non-toxic prodrugs programmed to be selectively activated by beta-glucuronidase present at high concentration in the microenvironment of most solid tumors has attracted considerable attention. This review summarizes the major progresses that have been realized in this field over the past ten years. This includes the new prodrugs that have been designed to target a wide variety of anticancer drugs, the prodrugs employed in the course of a combined therapy, the dendritic glucuronide prodrugs and the concept of β-glucuronidase-responsive albumin binding prodrugs.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Tranoy-Opalinski I,Legigan T,Barat R,Clarhaut J,Thomas M,Renoux B,Papot S

doi

10.1016/j.ejmech.2013.12.045

subject

Has Abstract

pub_date

2014-03-03 00:00:00

pages

302-13

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00007-5

journal_volume

74

pub_type

杂志文章

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