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Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-beta-CD and monoethanolamine and in vitro transdermal evaluation.

Abstract：

:Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-beta-CD. However, the DCF solubility increase was more significant by the addition of M-beta-CD in the presence of MEA. In vitro permeation experiments through excised human skin revealed that DCF was enhanced by M-beta-CD. Nevertheless, further improvement in the flux and the permeability coefficient of DCF was obtained by the ternary system DCF-M-beta-CD-MEA.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Mora MJ,Longhi MR,Granero GE

doi

10.1016/j.ejmech.2010.05.068

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

4079-88

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00439-3

journal_volume

45

pub_type

杂志文章

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