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Design, synthesis, and antiviral activity of novel rutin derivatives containing 1, 4-pentadien-3-one moiety.

Abstract：

:Rutin (compound 5) and some compounds (compounds 1-4 and 6) were isolated from Artemisia princeps Pamp (A. princeps Pamp.) and a series of novel rutin derivatives containing 1,4-pentadien-3-one moiety were designed and synthesized. The target compounds were characterized by proton nuclear magnetic resonance spectroscopy ((1)H NMR), carbon nuclear magnetic resonance spectroscopy ((13)C NMR), and ESI-MS. Bioassay results indicated that some of the compounds showed good to excellent antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) at 500 μg/mL in vivo. The 50% effective concentrations (EC50) of the compound 7r against CMV was 394.78 μg/mL, which was better than that of Ningnanmycin (432.22 μg/mL). These results indicated that novel rutin derivatives containing 1,4-pentadien-3-one moiety can effectively control CMV.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Han Y,Ding Y,Xie D,Hu D,Li P,Li X,Xue W,Jin L,Song B

doi

10.1016/j.ejmech.2015.01.017

subject

Has Abstract

pub_date

2015-03-06 00:00:00

pages

732-7

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(15)00037-9

journal_volume

92

pub_type

杂志文章

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