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Synthesis of novel cinnamanilides as potential immunosuppressive agents.

Abstract：

:A series of new cinnamanilides (6-40) were synthesized and their immunosuppressive activity and cytotoxicity were evaluated. Most of the cinnamanilides showed good immunosuppressive activity. Among the synthesized compounds, (Z)-N-(4-bromophenyl)-2-methoxy-3-(4-methoxyphenyl)acrylamide (37) and (Z)-2-methoxy-3-(4-methoxyphenyl)-N-p-tolylacrylamide (38) exhibited potent immunosuppressive activity (IC(50) = 1.77 ± 0.33 and 0.94 ± 0.13 μM) without significant cytotoxicity.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Shi L,Wang L,Wang Z,Zhu HL,Song Q

doi

10.1016/j.ejmech.2011.10.027

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

585-93

issue

1

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00766-5

journal_volume

47

pub_type

杂志文章

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