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Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines.

Abstract：

:A new series of indolo[1,2-c]quinazoline derivatives were prepared in good yield through reaction of 2-(o-aminophenyl)indole with a variety of arylaldehydes. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR and mass spectral studies and elemental analysis. All the title compounds were investigated for their activity against certain strains of Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Streptococcus pyogenes), Gram-negative bacteria (Salmonella typhimurium, Escherichia coli and Klebsiella pneumonia) and pathogenic Fungi (Aspergillus niger, Candida albicans and Trichoderma viridae). Ampicillin and ketoconazole were used as reference compounds. The results revealed that some of synthesized compounds displayed marked activity against all the tested microorganisms.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Rohini R,Muralidhar Reddy P,Shanker K,Hu A,Ravinder V

doi

10.1016/j.ejmech.2009.11.038

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1200-5

issue

3

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00608-4

journal_volume

45

pub_type

杂志文章

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