Abstract：
:The efficient synthesis of novel azetidin-2-ones 6 has been established. Thus, condensation of 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-amine 4 with various aromatic aldehydes afforded 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-N-[(substituted) phenylmethylidene]-1,3,4-thiadiazol-2-amine 5 which on cycloaddition with chloroacetyl chloride in the presence of triethylamine catalyst yielded 3-chloro-1-{5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-yl}-4-(substituted) phenylazetidin-2-one 6. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Ansari KF,Lal Cdoi
10.1016/j.ejmech.2008.01.022subject
Has Abstractpub_date
2009-05-01 00:00:00pages
2294-9issue
5eissn
0223-5234issn
1768-3254pii
S0223-5234(08)00046-9journal_volume
44pub_type
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