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Naphthalimide-based macrophage nucleus imaging probes.

Abstract：

:The photophysical properties of naphthalimide-based fluorophores can be easily tuned by chemical manipulation of the substituents on that privileged scaffold. Replacement of a OMe group at position 6 in 2-(hydroxyl)ethyl-naphthalimide derivatives by diverse amines, including 2-(hydroxyl)ethylamine, trans-(4-acetamido)cyclohexylamine and azetidine increases the solvatochromic (ICT) character, while this replacement in 2-(dimethylamino)ethyl-naphthalimide analogues (PET fluorophores) decrease their solvent polarity sensitivity or even reversed them to solvatochromic fluorophores. These fluorophores resulted macrophage nucleus imaging probes, which bind DNA as intercalants and showed low cytotoxicity in human cancer cells.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Fueyo-González F,Fernández-Gutiérrez M,García-Puentes D,Orte A,González-Vera JA,Herranz R

doi

10.1016/j.ejmech.2020.112407

subject

Has Abstract

pub_date

2020-08-15 00:00:00

pages

112407

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(20)30378-0

journal_volume

200

pub_type

杂志文章

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