Abstract:
:A new series of chiral 1,3,4-thiadiazoles derivatives possessing gamma-substituted butenolide moiety were synthesized and evaluated for in vitro anticancer properties. All the compounds showed good anticancer activities against Hela cell lines. Of all the studied compounds, compound 9e exhibited the best inhibitory activity with an IC(50) of 0.9 microM. After being treated with 0.1 microg/mL compound 9e for 24h, the growth inhibition rate of Hela cell lines was 59.2%.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Wei MX,Feng L,Li XQ,Zhou XZ,Shao ZHdoi
10.1016/j.ejmech.2009.03.023subject
Has Abstractpub_date
2009-08-01 00:00:00pages
3340-4issue
8eissn
0223-5234issn
1768-3254pii
S0223-5234(09)00162-7journal_volume
44pub_type
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