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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.

Abstract：

:A series of anthracenone-based oxime ethers and -esters were synthesized in order to evaluate their antiproliferative activity. Several investigated compounds displayed strong antiproliferative activity against K562 leukemia cells and proved to be strong inhibitors of tubulin polymerization. In this context, anthracenone-based oxime ethers and -esters are considered to contribute to the development of novel antiproliferative drugs, based on tubulin interaction.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Surkau G,Böhm KJ,Müller K,Prinz H

doi

10.1016/j.ejmech.2010.04.019

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

3354-64

issue

8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00301-6

journal_volume

45

pub_type

杂志文章

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