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Synthesis and in vitro cytotoxic activity of pyrrolo[2,3-e]indole derivatives and a dihydro benzoindole analogue.

Abstract：

:The synthesis of pyrrolo[2,3-e]indole derivatives with the structural characteristics of DNA bis- and mono-intercalators are described. A dihydro benzoindol analogue was also synthesised to elucidate the major structural requirements for cytotoxic activity. A biological evaluation of the test compounds was carried out in six different tumoral cell lines. The factors that affect the cytotoxic activity appear to be the substituents on the phenyl group, the presence of an amide group capable of strong interactions such as hydrogen bonding and solubility.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Chacón-García L,Martínez R

doi

10.1016/s0223-5234(01)01328-9

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

261-6

issue

3

eissn

0223-5234

issn

1768-3254

pii

S0223523401013289

journal_volume

37

pub_type

杂志文章

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