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Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles.

Abstract：

:A new series of novel 5-(nitro/bromo)-styryl-2-benzimidazoles (1-12) has been synthesized by simple, mild and efficient synthetic protocol by attempted condensation of 5-(nitro/bromo)-o-phenylenediamine with trans-cinnamic acids in ethylene glycol. Screening for in vitro anti-tubercular activity against Mycobacterium tuberculosis H(37) Rv, anti-bacterial activity against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae bacterial strains and anti-fungal activity against Candida albicans and Asperigillus fumigatus fungal strains were carried out. Compounds 5, 7, 8, 9, 11 showed higher anti-tubercular activity and compounds 7, 8, 10, 11, 12 have proved to be effective with MIC (microg/ml) and emerged as lead molecules showing excellent activities against a panel of microorganisms. All synthesized compounds were characterized using IR, (1)H, (13)C NMR, GC-MS and elemental analysis.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Shingalapur RV,Hosamani KM,Keri RS

doi

10.1016/j.ejmech.2009.05.021

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

4244-8

issue

10

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00316-X

journal_volume

44

pub_type

杂志文章

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