Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents.

Abstract:

:2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds 3a-g having structural features of styrylchromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds 3a-g were synthesized by the condensation of 2-methylchromone derivative 7 with several aromatic aldehydes. Among synthesized, compound 3e showed the significant cytotoxic activity on HCT-15 cell line with IC(50) values of 7.17 microg/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application.

journal_name

Eur J Med Chem

authors

Lee KY,Nam DH,Moon CS,Seo SH,Lee JY,Lee YS

doi

10.1016/j.ejmech.2006.04.008

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

991-6

issue

8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(06)00154-1

journal_volume

41

pub_type

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