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Promising applications of steroid сonjugates for cancer research and treatment.

Abstract：

:The conjugation of biologically active molecules is a powerful tool for drug discovery used to target a variety of multifunctional diseases including cancer. Conjugated drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. Steroids are widely used for conjugation with other biological active molecules. This review refers to investigations of steroid conjugates as potential anticancer agents carried out mostly over the past decade. It consists of five parts in which the data concerning structure and anticancer activity of steroid conjugates with DNA alkylating agents, metallocomplexes, approved drugs, some biological active molecules, some natural compounds and related synthetic analogs are described.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

А Zolottsev V,Latysheva АS,Pokrovsky VS,Khan II,Misharin AY

doi

10.1016/j.ejmech.2020.113089

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

113089

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(20)31061-8

journal_volume

210

pub_type

杂志文章,评审

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