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Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents.

Abstract：

:A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Sashidhara KV,Dodda RP,Sonkar R,Palnati GR,Bhatia G

doi

10.1016/j.ejmech.2014.04.085

subject

Has Abstract

pub_date

2014-06-23 00:00:00

pages

499-509

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(14)00456-5

journal_volume

81

pub_type

杂志文章

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