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Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes.

Abstract：

:Structural studies and an investigation of the cytotoxic activity of Sn(IV) complexes with N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) were carried out. The crystal and molecular structures of [Sn(2Bz4Ph)Cl3].CH3CH2OH (1) and [Sn(2Bz4Ph)BuCl2].H2O (Bu = butyl group) (2) were determined. Both compounds present octahedral coordination geometry with the 2Bz4Ph anionic ligand behaving as tridentate on the metal ion. A comparative study of the structures of these compounds along with that of [Sn(2Bz4Ph)Bu2Cl] (3) determined before is presented. The cytotoxicity of H2Bz4Ph and its Sn(IV) complexes was investigated against the MCF-7, TK-10 and UACC-62 human tumor cell lines. Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Perez-Rebolledo A,Ayala JD,de Lima GM,Marchini N,Bombieri G,Zani CL,Souza-Fagundes EM,Beraldo H

doi

10.1016/j.ejmech.2005.01.006

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

467-72

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(05)00017-6

journal_volume

40

pub_type

杂志文章

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