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Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives.

Abstract：

:Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide 5a was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Idrees GA,Abuo-Rahma Gel-D,Aly OM,Radwan MF

doi

10.1016/j.ejmech.2008.12.009

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

2679-84

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00598-9

journal_volume

44

pub_type

杂志文章

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