Abstract:
:Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. We have recently demonstrated that tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, tomatidine has shown antibiotic activity against small-colony variants of S. aureus. We herein report the first study of the structure-activity relationship of tomatidine against S. aureus.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Chagnon F,Guay I,Bonin MA,Mitchell G,Bouarab K,Malouin F,Marsault Édoi
10.1016/j.ejmech.2013.11.019subject
Has Abstractpub_date
2014-06-10 00:00:00pages
605-20eissn
0223-5234issn
1768-3254pii
S0223-5234(13)00761-7journal_volume
80pub_type
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