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Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide.

Abstract：

:Two novel series of 4-thiazolidinone derivatives, namely 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid [2-(5-nitro-2-furyl/substituted phenyl)-4-thiazolidinone-3-yl]amides (5a-g) and 2-(2',4'-difluoro-4-hydroxybiphenyl-3-carbonylhydrazono)-3-alkyl/aryl-4-thiazolidinones (6a-e) together with 5-(2',4'-difluoro-4-hydroxybiphenyl-5-yl)-2-cyclohexylamino-1,3,4-oxadiazole (7a) have been synthesized as title compounds. 1-(2',4'-Difluoro-4-hydroxybiphenyl-3-carbonyl)-4-alkyl/arylthiosemicarbazides (4a-g) were also obtained and used as intermediate to give the title compounds. All synthesized compounds were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv, antiviral and antimicrobial activities against various virus, bacteria and fungi strains.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Küçükgüzel G,Kocatepe A,De Clercq E,Sahin F,Güllüce M

doi

10.1016/j.ejmech.2005.11.005

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

353-9

issue

3

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(05)00314-4

journal_volume

41

pub_type

杂志文章

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