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A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury.

Abstract：

:We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Bi W,Bi Y,Xue P,Zhang Y,Gao X,Wang Z,Li M,Baudy-Floc'h M,Ngerebara N,Gibson KM,Bi L

doi

10.1016/j.ejmech.2011.01.021

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1453-62

issue

5

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00041-9

journal_volume

46

pub_type

杂志文章

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