当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Antidyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases.

Antidyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases.

Abstract：

:8-Hydroxyquinoline when subjected to Duff reaction resulted in the formation of unexpected 7-methylaminomethylene-8-oxo-7, 8-dihydroquinoline-5-carbaldehyde 2, which existed in the keto-enamine form, in which the aromaticity of the relevant ring was disrupted, which upon subsequent treatment with various primary amines resulted in its nucleophilic substitution of aliphatic methyl amine. These interesting novel derivatives were evaluated in vitro for their antioxidant and in vivo for their antidyslipidemic and post-heparin lipolytic activities. Compound 6 was found to be most active antidyslipidemic and antioxidative agent in this series, respectively, and thus represent a new class of promising lead.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Sashidhara KV,Kumar A,Bhatia G,Khan MM,Khanna AK,Saxena JK

doi

10.1016/j.ejmech.2008.08.004

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1813-8

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00363-2

journal_volume

44

pub_type

杂志文章

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