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Structure activity relationships of quinoline-containing c-Met inhibitors.

Abstract：

:A series of quinoline-containing c-Met inhibitors were prepared and studied. Chemistry was developed to introduce a pyridyl moiety onto the 2-aryl ring present in a lead molecule which mitigated the potential for quinone formation relative to the original compound. The study also assessed the importance of an acylthiourea moiety present in the lead structure for effective binding to the c-Met protein ATP site.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Kung PP,Funk L,Meng J,Alton G,Padrique E,Mroczkowski B

doi

10.1016/j.ejmech.2007.08.011

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

1321-9

issue

6

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(07)00333-9

journal_volume

43

pub_type

杂志文章

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