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Synthesis and antitumour activity of a new series of nitrosoureido sugars.

Abstract：

:New nitrosoureido derivatives of di- or tri-deoxy-sugars have been synthesized. Very potent antitumour activity against L1210 leukaemia was exhibited by the compounds derived from methyl 3-amino-3, 4-dideoxy-beta- and alpha- and 4-amino-2,4-dideoxy-beta- and alpha-D-arabino-hexopyranosides, 24, 26, 28 and 29, respectively. In further evaluation against B16 melanocarcinoma bearing mice, only compounds 24 and 26 displayed significant activity. Owing to its lower acute toxicity, methyl 3-[3-(2-chloroethyl)-3-nitrosoureido]-3, 4-dideoxy-beta-D-arabino-hexopyranoside 24 appeared as the best candidate for preclinical studies.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Monneret C,Rissé S,Ardouin P,Gouyette A

doi

10.1016/s0223-5234(00)00114-8

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

137-46

issue

1

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(00)00114-8

journal_volume

35

pub_type

杂志文章

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