当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Abstract：

:We describe the design, synthesis, and biological evaluation of a series of novel HIV-1 protease inhibitors with carboxamide derivatives as the P2 ligands. We have specifically designed aminothiochromane and aminotetrahydronaphthalene-based carboxamide ligands to promote hydrogen bonding and van der Waals interactions in the active site of HIV-1 protease. Inhibitors 4e and 4j have shown potent enzyme inhibitory and antiviral activity. High resolution X-ray crystal structures of 4d- and 4k-bound HIV-1 protease revealed molecular insights into the ligand-binding site interactions.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Ghosh AK,Jadhav RD,Simpson H,Kovela S,Osswald H,Agniswamy J,Wang YF,Hattori SI,Weber IT,Mitsuya H

doi

10.1016/j.ejmech.2018.09.046

subject

Has Abstract

pub_date

2018-12-05 00:00:00

pages

171-182

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(18)30818-3

journal_volume

160

pub_type

杂志文章

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