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Novel cajaninstilbene acid derivatives as antibacterial agents.

Abstract：

:Discovery of novel antibacterial agents with new structural scaffolds that combat drug-resistant pathogens is an urgent task. Cajaninstilbene acid, which is isolated from pigeonpea leaves, has shown antibacterial activity. In this study, a series of cajaninstilbene acid derivatives were designed and synthesized. The antibacterial activities of these compounds against gram-negative and gram-positive bacteria, as well as nine strains of methicillin-resistant staphylococcus aureus (MRSA) bacteria are evaluated，and the related structure-activity relationships are discussed. Assays suggest that some of the synthetic cajaninstilbene acid derivatives exhibit potent antibacterial activity against gram-positive bacterial strains and MRSA. Among these compounds, 5b, 5c, 5j and 5k show better antibacterial activity than the positive control compounds. The results of MTT assays illustrate the low cytotoxicity of the active compounds.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Geng ZZ,Zhang JJ,Lin J,Huang MY,An LK,Zhang HB,Sun PH,Ye WC,Chen WM

doi

10.1016/j.ejmech.2015.06.008

subject

Has Abstract

pub_date

2015-07-15 00:00:00

pages

235-45

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(15)30083-0

journal_volume

100

pub_type

杂志文章

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