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Novel inhibitors of nitric oxide synthase with antioxidant properties.

Abstract：

:We previously described a series of imidazole-based inhibitors substituted at N-1 with an arylethanone chain as interesting inhibitors of neuronal nitric oxide synthase (nNOS), endowed with good selectivity vs endothelial nitric oxide synthase (eNOS). As a follow up of these studies, several analogs characterized by the presence of substituted imidazoles or other mono or bicyclic nitrogen-containing heterocycles instead of simple imidazole were synthesized, and their biological evaluation as in vitro inhibitors of both nNOS and eNOS is described herein. Most of these compounds showed improved nNOS and eNOS inhibitory activity with respect to reference inhibitors. Selected compounds were also tested to analyze their antioxidant properties. Some of them displayed good capacity to scavenge free radicals and ability to reduce lipid peroxidation.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Salerno L,Modica MN,Romeo G,Pittalà V,Siracusa MA,Amato ME,Acquaviva R,Di Giacomo C,Sorrenti V

doi

10.1016/j.ejmech.2012.01.002

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

118-26

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(12)00003-7

journal_volume

49

pub_type

杂志文章

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