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2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.

Abstract：

:Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in rats, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Wang Y,Zhang H,Huang W,Kong J,Zhou J,Zhang B

doi

10.1016/j.ejmech.2008.09.033

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1638-43

issue

4

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(08)00423-6

journal_volume

44

pub_type

杂志文章

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