当前位置： SCI文献检索 > EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).

Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).

Abstract：

:A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the flavones were incompletely described.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Mai LH,Chabot GG,Grellier P,Quentin L,Dumontet V,Poulain C,Espindola LS,Michel S,Vo HT,Deguin B,Grougnet R

doi

10.1016/j.ejmech.2015.01.012

subject

Has Abstract

pub_date

2015-03-26 00:00:00

pages

93-100

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(15)00032-X

journal_volume

93

pub_type

杂志文章

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